Detection and analysis of ancient segmental duplications in mammalian genomes
نویسندگان
چکیده
منابع مشابه
Quantifying the mechanisms for segmental duplications in mammalian genomes by statistical analysis and modeling.
A large number of the segmental duplications in mammalian genomes have been cataloged by genome-wide sequence analyses. The molecular mechanisms involved in these duplications mostly remain a matter of speculation. To uncover, test, and further quantify the hypotheses on the mechanisms for the recent duplications in the mammalian genomes, we have performed a series of statistical analyses on th...
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MOTIVATION Large-scale evolutionary events such as genomic rearrange.ments and segmental duplications form an important part of the evolution of genomes and are widely studied from both biological and computational perspectives. A basic computational problem is to infer these events in the evolutionary history for given modern genomes, a task for which many algorithms have been proposed under v...
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Evolution of organismal complexity and origin of novelties during vertebrate history has been widely explored in context of both regulation of gene expression and gene duplication events. Ohno (1970) for the first time put forward the idea of two rounds whole genome duplication events as the most plausible explanation for evolutionarizing the vertebrate lineage (2R hypothesis). To test the vali...
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We show that textual analysis of microbial genomes reveal telling footprints of the early evolution of the genomes. The frequencies of word occurrence of random DNA sequences considered as texts in their four nucleotides are expected to obey Poisson distributions. It is noticed that for words less than nine letters the average width of the distributions for complete microbial genomes is many ti...
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A DNA sequence can be analyzed as a text of four letters by counting the times each word in the set of k-letter words occurs in the text. If the text is random and long enough, then the frequencies of word occurrence are expected to obey a Poisson distribution. Examination of complete microbial genomes shows that for k less than 9, the distribution has a width many times the width of a Poisson ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2018
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.228718.117